A drive circuit for a serial communications system is provided. The drive circuit may include a mode controller, a pre-drive circuit, and a main drive circuit. The main drive circuit includes multiple mode control switches and at least one pair of differential switches. The mode controller is configured to: generate a mode control signal, and transmit the mode control signal to the main drive circuit. The pre-drive circuit is configured to: convert a differential digital signal into a differential control signal, and transmit the differential control signal to the main drive circuit. The main drive circuit controls on/off states of the multiple mode control switches according to the mode control signal, and works in corresponding working modes. The drive circuit controls the states of the mode control switches in the main drive circuit, so that the main drive circuit works in different working modes.