A high-performance fenestration system that includes a pressure chamber formed between longitudinally adjacent fenestration members. The pressure chamber is positioned on one side of the thermal break. The fenestration system can be configured so to create a continuous pressure chamber around the closed perimeter of the fenestration between the frame and sash. The resulting fenestration system enjoys significantly better water penetration resistance as compared with conventional high-performance doors and windows. Because of the positioning and structural configuration of the pressure chamber, the fenestration system can be configured to accept different hinge styles including Euro-style and American-style hinges without significant loss of performance. In addition, the system can accept American-style door hardware or Euro-style door hardware.