发明申请
- 专利标题： NEPRILYSIN INHIBITORS
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申请号： US15696713申请日： 2017-09-06
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公开(公告)号： US20180118696A1公开(公告)日： 2018-05-03
- 发明人: Melissa Fleury , Anne-Marie Beausoleil , Adam D. Hughes , Daniel D. Long , Donna A.A. Wilton
- 申请人： THERAVANCE BIOPHARMA R&D IP, LLC
- 申请人地址： US CA South San Francisco
- 专利权人： THERAVANCE BIOPHARMA R&D IP, LLC
- 当前专利权人： THERAVANCE BIOPHARMA R&D IP, LLC
- 当前专利权人地址： US CA South San Francisco
- 主分类号： C07D249/04
- IPC分类号： C07D249/04 ; C07D249/10 ; C07D231/14 ; C07D261/18 ; C07D263/34 ; C07D263/38 ; C07D271/07 ; C07D239/28 ; C07D231/20 ; C07D275/03 ; C07D471/04 ; C07D403/12 ; C07D213/81
摘要：
In one aspect, the invention relates to compounds having the formula I: where R1-R6 are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising these compounds; methods of using these compounds; and processes and intermediates for preparing these compounds.
公开/授权文献
- US10005740B2 Neprilysin inhibitors 公开/授权日：2018-06-26
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