- 专利标题: SUBSTITUTED TRICYCLIC HETEROCYCLIC COMPOUNDS
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申请号: US15558692申请日: 2016-03-17
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公开(公告)号: US20180111936A1公开(公告)日: 2018-04-26
- 发明人: Hai-Yun XIAO , Murali T.G. DHAR , Jingwu DUAN , Bin JIANG , Andrew J. TEBBEN
- 申请人: BRISTOL-MYERS SQUIBB COMPANY
- 国际申请: PCT/US2016/022737 WO 20160317
- 主分类号: C07D471/14
- IPC分类号: C07D471/14 ; A61P37/00 ; A61P29/00
摘要:
Disclosed are compounds of Formula (I) or a salt thereof, wherein: X is N; W is: (i) —(CR3R3)1-4—; (ii) —(CR3R3)x—Y—(CR3R3)y—; Or (iii) —Y—(CR3R3)2—Y—; and Y, R1, R2, R3, R5, R6, R8, x, and y are defined herein. Also disclosed are methods of using such compounds as modulators of TNFα, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.
公开/授权文献
- US10189840B2 Substituted tricyclic heterocyclic compounds 公开/授权日:2019-01-29
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