A system for self-organized acoustic signal cancellation over a network is disclosed. The system may transmit an acoustic sounding signal to an interfering device so that a channel measurement may be performed for a channel between the interfering device and an interferee device. The system may receive the channel measurement for the channel from the interfering device and also receive a digitized version of an audio interference signal associated with the interfering device. Based on the channel measurement and the digital version of the interference signal, the system may calculate a cancellation signal prior to the arrival of the original over-the-air audio interference signal that corresponds to the digital version of audio interference signal. The system may then apply the cancellation signal to an audio signal associated with the interferee device to remove the interference signal from the audio signal.