Golf balls having an initial velocity greater than 255 ft/sec and/or an overall distance of greater than 320 yards are disclosed. The golf balls comprise one or more core layers, one or more cover layers, and optionally one or more intermediate layers disposed between the core and the cover. At least one layer is optionally formed from a composition comprising from 2 wt % to 50 wt % of a plasticizer, based on the total weight of the composition.