Invention Application
- Patent Title: 8-AZABICYCLO[3.2.1]OCTANE COMPOUNDS AS MU OPIOID RECEPTOR ANTAGONISTS
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Application No.: US15496269Application Date: 2017-04-25
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Publication No.: US20170349578A1Publication Date: 2017-12-07
- Inventor: Daniel D. Long , John R. Jacobsen , Lan Jiang
- Applicant: THERAVANCE BIOPHARMA R&D IP, LLC
- Applicant Address: US CA South San Francisco
- Assignee: THERAVANCE BIOPHARMA R&D IP, LLC
- Current Assignee: THERAVANCE BIOPHARMA R&D IP, LLC
- Current Assignee Address: US CA South San Francisco
- Main IPC: C07D451/02
- IPC: C07D451/02 ; A61K31/485 ; A61K31/46 ; A61K45/06 ; A61K31/439
![8-AZABICYCLO[3.2.1]OCTANE COMPOUNDS AS MU OPIOID RECEPTOR ANTAGONISTS](/abs-image/US/2017/12/07/US20170349578A1/abs.jpg.150x150.jpg)
Abstract:
The invention provides novel 8-azabicyclo[3.2.1]octane compounds of formula (I): wherein R1, R2, R3, A, and G are defined in the specification, or a pharmaceutically-acceptable salt or solvate thereof, that are antagonists at the mu opioid receptor. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat conditions associated with mu opioid receptor activity, and processes and intermediates useful for preparing such compounds.
Public/Granted literature
- US10081626B2 8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists Public/Granted day:2018-09-25
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