Filter media comprising a filtration layer comprising synthetic fibers (e.g., pleatable backer layer) and related components, systems, and methods associated herewith are provided. In some embodiments, the filtration layer comprising synthetic fibers may be a non-woven web comprising a blend of coarse and fine diameter fibers. The filtration layer comprising synthetic fibers may be designed to have desirable performance properties without compromising certain mechanical properties, such as the pleatability of the media. In some embodiments, a filter media, described herein, may comprise the filtration layer comprising synthetic fibers and an efficiency layer. Filter media, as described herein, may be particularly well-suited for applications that involve filtering air, though the media may also be used in other applications.