Invention Application
- Patent Title: QUINOLONE DERIVATIVES AS ANTIBACTERIALS
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Application No.: US15500870Application Date: 2015-08-03
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Publication No.: US20170217897A1Publication Date: 2017-08-03
- Inventor: Javier de Vicente FIDALGO , Haiying HE , Cheng HU , Zhigan JIANG , Xiaolin LI , Peichao LU , Wosenu MERGO , Daniel MUTNICK , Folkert RECK , Alexey RIVKIN , Colin Keith SKEPPER , Xiaojing Michael WANG , Jianhua XIA , Yongjin XU
- Applicant: Zhigan JIANG , Jianhua XIA , Haiying HE , NOVARTIS AG
- Priority: CNPCT/CN2014/083811 20140806
- International Application: PCT/IB2015/055899 WO 20150803
- Main IPC: C07D215/38
- IPC: C07D215/38 ; A61K31/4709 ; A61K31/496 ; C07D401/14 ; C07D413/14 ; C07D419/14 ; C07D405/14 ; C07D471/04 ; C07D498/10 ; A61K31/5377 ; A61K31/5386 ; C07D487/10 ; C07D471/10 ; A61K45/06 ; C07D401/04
Abstract:
This invention is in the field of medicinal chemistry and relates to compounds, and pharmaceutical compositions thereof, that inhibit bacterial gyrase. The compounds are useful as inhibitors of bacterial gyrase activity and bacterial infections, and have the structure of Formula (I) as further described herein. The invention further provides pharmaceutical compositions comprising a compound of Formula (I) and methods of using the compounds and compositions to treat bacterial infections.
Public/Granted literature
- US10160726B2 Quinolone derivatives as antibacterials Public/Granted day:2018-12-25
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