A treatment method that increases circulation and pluripotency of stem and progenitor cells within a patient can be used to fight off or cure various diseases for the patient such as chronic kidney disease or end-stage renal disease. An administrator of the treatment method is provided with a medicinal-administration system such as an intravenous injection system. The treatment method begins by preparing a dosage of oxygen-ozone mixture with the medicinal-administration system. The medicinal-administration system then transfuses the oxygen-ozone mixture in the patient's bloodstream so that the renal system and/or the bone marrow can be targeted by the oxygen-ozone mixture. These steps are repeated as a plurality of treatment session for the patient.