- 专利标题： HISTONE ACETYLTRANSFERASE MODULATORS AND USES THEREOF
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申请号： US13996483申请日： 2011-12-22
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公开(公告)号： US20170121276A1公开(公告)日： 2017-05-04
- 发明人: Yitshak FRANCIS , Mauro FA , Ottavio ARANCIO , Jole FIORITO , Shixian DENG , Donald W. LANDRY , Michal LUZAC , Yan FENG
- 申请人： Yitshak FRANCIS , Mauro FA , Ottavio ARANCIO , Jole FIORITO , Shixian DENG , Donald W. LANDRY , Michal LUZAC , Yan FENG
- 申请人地址： US NY New York
- 专利权人： The Trustees of Columbia University in the City of New York
- 当前专利权人： The Trustees of Columbia University in the City of New York
- 当前专利权人地址： US NY New York
- 国际申请： PCT/US11/66851 WO 20111222
- 主分类号： C07C217/22
- IPC分类号： C07C217/22 ; C07D295/088 ; C07D265/14 ; C07D209/48
摘要：
The invention provides compounds and compositions comprising compounds that modulate histone acyl transferase (HAT). The invention further provides methods for treating neurodegenerative disorders, conditions associated with accumulated amyloid-beta peptide deposits, Tau protein levels, and/or accumulations of alpha-synuclein as well as cancer by administering a compound that modulates HAT to a subject.
公开/授权文献
- US09969677B2 Histone acetyltransferase modulators and uses thereof 公开/授权日：2018-05-15
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