Mechanisms are provided for implementing a personalized patient care plan (PPCP) system. The PPCP system obtains personal and medical information about the patient and generates a patient registry record in a patient registry. The PPCP system generates a PPCP for the patient, comprising a sequence of goals for the patient, based on an analysis of the obtained personal and medical information. Each goal has an associated patient action to be performed by the patient. The PPCP system monitors performance of the goals to determine, for each goal, whether the associated patient action is performed by the patient. In response to determining that the patient did not perform an associated patient action, the PPCP system modifies a goal of the personalized patient care plan to replace the associated patient action with a replacement patient action that is more likely to be performed by the patient.