A method for filling an aseptic pouch having the steps of: (a) providing a pouch, the pouch including a body having a plurality of panels coupled together to define a cavity, and, a spout providing ingress into the cavity, the spout having a plug sealingly engaged to the spout; (b) cleaning the external surfaces of the pouch with a cleaning preparation; (c) directing the spout and the plug into an aseptic zone, the aseptic zone having a supply of sterilized gas having a positive flow within the aseptic zone; (d) removing the plug; (e) filling the pouch with a flowable material; (f) replacing the plug on the spout to seal the cavity; (g) removing the spout and the plug from the aseptic zone; and (h) coupling the plug to a cap, and the cap to the spout, whereupon removal of the cap removes the plug, providing cavity access.