发明申请
US20170043028A1 NOVEL USE OF MULTI-ARM POLYETHYLENE GLYCOL MODIFIER AND APPLICATION OF MULTI-ARM POLYETHYLENE GLYCOL MODIFIER IN L-ASPARAGINASUM MODIFICATION
审中-公开
多臂聚乙烯甘油改性剂的新用途及多糖聚乙二醇改性剂在L-阿魏酸改性中的应用
- 专利标题： NOVEL USE OF MULTI-ARM POLYETHYLENE GLYCOL MODIFIER AND APPLICATION OF MULTI-ARM POLYETHYLENE GLYCOL MODIFIER IN L-ASPARAGINASUM MODIFICATION
- 专利标题（中）： 多臂聚乙烯甘油改性剂的新用途及多糖聚乙二醇改性剂在L-阿魏酸改性中的应用
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申请号： US15109304申请日： 2014-07-28
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公开(公告)号： US20170043028A1公开(公告)日： 2017-02-16
- 发明人: Bruce Yong MA , Jun WANG , Dinglong WU , Chunlin XU , Yaofang WANG
- 申请人： ZONHON BIOPHARMA INSTITUTE INC. , GENSUN INSTITUTE OF BIOMEDICINE CO.,LTD.
- 申请人地址： CN Changzhou, Jiangsu CN Wujin Changzhou, Jiangsu
- 专利权人： ZONHON BIOPHARMA INSTITUTE INC.,GENSUN INSTITUTE OF BIOMEDICINE CO.,LTD.
- 当前专利权人： ZONHON BIOPHARMA INSTITUTE INC.,GENSUN INSTITUTE OF BIOMEDICINE CO.,LTD.
- 当前专利权人地址： CN Changzhou, Jiangsu CN Wujin Changzhou, Jiangsu
- 优先权： CN201310745273.4 20131230
- 国际申请： PCT/CN2014/083143 WO 20140728
- 主分类号： A61K47/48
- IPC分类号： A61K47/48 ; A61K9/00 ; A61K9/19 ; C12N9/96 ; C12N9/82 ; C12N9/80 ; C12N9/06 ; C12N9/16 ; A61K38/50 ; A61K38/44
摘要：
Methods for use of a multi-arm polyethylene glycol (PEG) modifier in modification of asparaginase. The described multi-arm PEG modifier enhances the subunit interaction of a multimeric protein to maintain the multimeric protein in a polymerized form, thereby improving the stability of the multimeric protein, maintaining the bioactivity of the multimeric protein, and reducing the probability of exposure of the antigen binding site after depolymerization of the subunits, so as to reduce the immunogenicity.
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