Invention Application
- Patent Title: RNAi Therapy for Hepatitis B Virus Infection
- Patent Title (中): RNAi治疗乙型肝炎病毒感染
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Application No.: US15229314Application Date: 2016-08-05
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Publication No.: US20170035796A1Publication Date: 2017-02-09
- Inventor: Christine I. Wooddell , David B. Rozema , David L. Lewis , Darren H. Wakefield , Lauren J. Almeida
- Applicant: Arrowhead Pharmaceuticals, Inc.
- Main IPC: A61K31/713
- IPC: A61K31/713 ; A61K38/16
Abstract:
Described are compositions and methods for inhibition of Hepatitis B virus gene expression. RNA interference (RNAi) triggers and RNAi trigger conjugates for inhibiting the expression of Hepatitis B virus gene are described. Pharmaceutical compositions comprising one or more HBV RNAi triggers optionally with one or more additional therapeutics are also described. Delivery of the described HBV RNAi triggers to infected liver in vivo provides for inhibition of HBV gene expression and treatment.
Public/Granted literature
- US10130651B2 RNAi Therapy for Hepatitis B Virus Infection Public/Granted day:2018-11-20
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