Invention Application
US20170002006A1 MACROCYCLES WITH HETROCYCLIC P2' GROUPS AS FACTOR XIA INHIBITORS
审中-公开
作为因子XIA抑制剂的HETROCYCLIC P2'组合物
- Patent Title: MACROCYCLES WITH HETROCYCLIC P2' GROUPS AS FACTOR XIA INHIBITORS
- Patent Title (中): 作为因子XIA抑制剂的HETROCYCLIC P2'组合物
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Application No.: US15115327Application Date: 2015-01-30
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Publication No.: US20170002006A1Publication Date: 2017-01-05
- Inventor: James R. Corte , Indawati De Lucca , Tianan Fang , Wu Yang , Yufeng Wang , Andrew K. Dilger , Kumar Balashanmuga Pabbisetty , William R. Ewing , Yeheng Zhu , Ruth R. Wexler , Donald J.P. Pinto , Michael J. Orwat , Leon M. Smith, II
- Applicant: BRISTOL-MYERS SQUIBB COMPANY
- International Application: PCT/US2015/013654 WO 20150130
- Main IPC: C07D471/18
- IPC: C07D471/18 ; C07D487/08

Abstract:
The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective factor XIa inhibitors or dual inhibitors of FXIa and plasma kallikrein. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same.
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