- 专利标题： FRIZZLED-BINDING AGENTS AND USES THEREOF
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申请号： US15003322申请日： 2016-01-21
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公开(公告)号： US20160326259A1公开(公告)日： 2016-11-10
- 发明人: Austin L. Gurney , Aaron Ken Sato , Fumiko Takada Axelrod , Timothy Chartes Hoey , Sanjeev H. Satyal , Satyajit Sujit Kumar Mitra
- 申请人： OncoMed Pharmaceuticals, Inc.
- 主分类号： C07K16/30
- IPC分类号： C07K16/30 ; A61K31/7068 ; A61K31/337 ; A61K39/395 ; A61K45/06
摘要：
Novel anti-cancer agents, including, but not limited to, antibodies, that bind to human frizzled receptors are provided. Novel epitopes within the human frizzled receptors which are suitable as targets for anti-cancer agents are also identified. Methods of using the agents or antibodies, such as methods of using the agents or antibodies to inhibit Wnt signaling and/or inhibit tumor growth are further provided.
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