发明申请
US20160310489A1 CARBOSTYRIL DERIVATIVES AND SEROTONIN REUPTAKE INHIBITORS FOR TREATMENT OF MOOD DISORDERS
审中-公开
CARBOSTYRIL衍生物和用于治疗遗传疾病的丝氨酸蛋白酶抑制剂
- 专利标题： CARBOSTYRIL DERIVATIVES AND SEROTONIN REUPTAKE INHIBITORS FOR TREATMENT OF MOOD DISORDERS
- 专利标题（中）： CARBOSTYRIL衍生物和用于治疗遗传疾病的丝氨酸蛋白酶抑制剂
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申请号： US15176464申请日： 2016-06-08
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公开(公告)号： US20160310489A1公开(公告)日： 2016-10-27
- 发明人: Tetsuro Kikuchi , Taro Iwamoto , Tsuyoshi Hirose
- 申请人： Otsuka Pharmaceutical Co., Ltd.
- 优先权： JP2002-379003 20021227
- 主分类号： A61K31/496
- IPC分类号： A61K31/496 ; A61K31/138 ; A61K31/381 ; A61K31/135 ; A61K31/165 ; A61K31/15 ; A61K31/4525 ; A61K31/343 ; A61K31/137
摘要：
The pharmaceutical composition of the present invention comprises (1) a carbostyril derivative and (2) a serotonin reuptake inhibitor in a pharmaceutically acceptable carrier. The carbostyril derivative may be aripiprazole or a metabolite thereof, which is a dopamine-serotonin system stabilizer. The serotonin reuptake inhibitor may be fluoxetine, duloxetine, venlafaxine, milnacipran, citalopram, fluvoxamine, paroxetine, sertraline or escitalopram. The pharmaceutical composition of the present invention is useful for treating patients with mood disorders, particularly depression or major depressive disorder.
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