Methods, devices and computer readable instructions to generate region-of-interest (ROI) tone curves are disclosed. One method includes obtaining a statistic for an entire image such as, for example, a luminance statistic. The same statistic may then be found for a specified ROI of the image. A weighted combination of the statistic of the entire image and the statistic of the ROI yields a combined statistic which may then be converted to a ROI-biased tone curve. The weight used to combine the two statistics may be selected to emphasize or de-emphasize the role of the ROI's statistic in the final tone curve.