Invention Application
- Patent Title: Inhibitors of the Renal Outer Medullary Potassium Channel
- Patent Title (中): 肾外侧髓质钾通道抑制剂
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Application No.: US14908222Application Date: 2014-07-28
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Publication No.: US20160207922A1Publication Date: 2016-07-21
- Inventor: Haifeng Tang , Barbara Pio , Jinlong Jiang , Alexander Pasternak , Shuzhi Dong , Ronald Dale Ferguson, II , Zack Zhiqiang Guo , Harry Chobanian , Jessica Frie , Yan Guo , Zhicai Wu , Yang Yu , Ming Wang
- Applicant: Merck Sharp & Dohme Corp.
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway
- International Application: PCT/US2014/048358 WO 20140728
- Main IPC: C07D471/10
- IPC: C07D471/10 ; A61K45/06 ; A61K31/435 ; A61K31/506 ; A61K31/5386 ; C07D451/00 ; A61K31/46 ; A61K31/497 ; C07D498/10 ; A61K31/444 ; A61K31/501
Abstract:
The present invention provides compounds of Formula I and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and chronic kidney disease and conditions associated with excessive salt and water retention.
Public/Granted literature
- US09751881B2 Inhibitors of the renal outer medullary potassium channel Public/Granted day:2017-09-05
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