Invention Application
US20160200715A1 PREPARATION AND USE OF 7A-HETEROCYCLE SUBSTITUTED- 6,6-DIFLUORO BICYCLIC HIMBACINE DERIVATIVES AS PAR-1 RECEPTOR ANTAGONISTS
审中-公开
作为PAR-1受体拮抗剂的7-取代的6,6-二氟基双环衍生物的制备和使用
- Patent Title: PREPARATION AND USE OF 7A-HETEROCYCLE SUBSTITUTED- 6,6-DIFLUORO BICYCLIC HIMBACINE DERIVATIVES AS PAR-1 RECEPTOR ANTAGONISTS
- Patent Title (中): 作为PAR-1受体拮抗剂的7-取代的6,6-二氟基双环衍生物的制备和使用
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Application No.: US14912212Application Date: 2014-08-18
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Publication No.: US20160200715A1Publication Date: 2016-07-14
- Inventor: Zhiqiang Yang , Guizhen Dong , Milana Maletic
- Applicant: Zhiqiang YANG , Guizhen DONG , Milana MALETIC , MERCK SHARP & DOHME CORP.
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway
- International Application: PCT/US14/51403 WO 20140818
- Main IPC: C07D413/14
- IPC: C07D413/14 ; A61K31/444 ; C07D405/14 ; A61K31/4439 ; A61K45/06
Abstract:
The present invention relates to bicyclic himbacine derivatives of the formula or a pharmaceutically acceptable salt thereof wherein: R1 is W is and the remaining variables are described herein. The compounds of the invention are effective inhibitors of the PAR-1 receptor. The inventive compounds may be used for the treatment or prophylaxis of disease states such as ASC, secondary prevention of myocardial infarction or stroke, or PAD.
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