发明申请
- 专利标题： ANTIBODIES WITH ENHANCED OR SUPPRESSED EFFECTOR FUNCTION
- 专利标题（中）： 具有增强或抑制效应的功能的抗体
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申请号： US15046379申请日： 2016-02-17
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公开(公告)号： US20160159921A1公开(公告)日： 2016-06-09
- 发明人: Igor D'Angelo , Dustin Bleile , Stacey A.L. Tom-Yew , Eric Escobar-Cabrera , Paula I. Lario , Anders Ohrn , David K.Y. Poon , Surjit B. Dixit
- 申请人： Zymeworks Inc.
- 主分类号： C07K16/32
- IPC分类号： C07K16/32 ; C07K16/08 ; C07K16/28
摘要：
Rationally designed antibodies and polypeptides that comprise multiple Fc region amino acid substitutions that synergistically provide enhanced selectivity and binding affinity to a target Fc receptor are provided. The polypeptides are mutated at multiple positions to make them more effective when incorporated in antibody therapeutics than those having wild-type Fc components.
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