发明申请
US20160152634A1 THIENO- AND FURO - PYRIMIDINES AND PYRIDINES, USEFUL AS POTASSIUM CHANNEL INHIBITORS
审中-公开
有益于磷酸盐通道抑制剂的三苯并呋喃酮和吡啶类和吡啶类
- 专利标题： THIENO- AND FURO - PYRIMIDINES AND PYRIDINES, USEFUL AS POTASSIUM CHANNEL INHIBITORS
- 专利标题（中）： 有益于磷酸盐通道抑制剂的三苯并呋喃酮和吡啶类和吡啶类
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申请号： US15016846申请日： 2016-02-05
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公开(公告)号： US20160152634A1公开(公告)日： 2016-06-02
- 发明人: David Madge , Fiona Chan , Derek Edward John , Simon D. Edwards , Richard Blunt , Basil Hartzoulakis , Lindsay Brown
- 申请人： XENTION LIMITED
- 优先权： GB1119703.5 20111115; GB1214250.1 20120809
- 主分类号： C07D495/04
- IPC分类号： C07D495/04 ; C07D491/048
摘要：
The present invention provides compounds of formula (I): (Formula (I)); wherein A, R1, R2, R3I, V, X, and Z are defined herein, which are potassium channel inhibitors. The invention further provides pharmaceutical compositions comprising the compounds of formula (I) and their use in therapy, in particular in treatment of diseases or conditions that are mediated by Kir3.1 and/or Kir3.4 or any heteromultimers thereof, or that require inhibition of Kir3.1 and/or Kir3.4 or any heteromultimers thereof.
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