发明申请
US20160069866A1 INHIBITION OF THE BETA3 SUBUNIT OF L-TYPE CA2+ CHANNELS
审中-公开
L型CA2 +通道的BETA3亚基的抑制作用
- 专利标题： INHIBITION OF THE BETA3 SUBUNIT OF L-TYPE CA2+ CHANNELS
- 专利标题（中）： L型CA2 +通道的BETA3亚基的抑制作用
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申请号： US14927448申请日： 2015-10-29
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公开(公告)号： US20160069866A1公开(公告)日： 2016-03-10
- 发明人: Per-Olof Berggren , Veit Flockerzi
- 申请人： Biocrine AB
- 主分类号： G01N33/50
- IPC分类号： G01N33/50 ; C07K14/705
摘要：
The present invention provides reagents and methods for identifying inhibitors of the L-type Ca2+ channel β3 protein, which has been demonstrated to be involved in calcium signaling, insulin secretion, and glucose homeostasis. The invention also provides therapeutics and methods for treating a subject with one or more of diabetes, insulin resistance, impaired insulin secretion, and impaired glucose homeostasis, involving the use of inhibitors of an L-type Ca2+ channel β3 subunit to provide a benefit to the subject.
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