发明申请
- 专利标题: NOVEL ANTI-HUMAN TSLP RECEPTOR ANTIBODY
- 专利标题(中): 新型抗人TSLP受体抗体
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申请号: US14927007申请日: 2015-10-29
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公开(公告)号: US20160046720A1公开(公告)日: 2016-02-18
- 发明人: Hiromu SATO , Daisuke Yamajuku , Kazunori Arai , Mako Ogino
- 申请人: Astellas Pharma Inc.
- 申请人地址: JP Tokyo
- 专利权人: Astellas Pharma Inc.
- 当前专利权人: Astellas Pharma Inc.
- 当前专利权人地址: JP Tokyo
- 优先权: JP2013-165676 20130809
- 主分类号: C07K16/28
- IPC分类号: C07K16/28
摘要:
[Problem] To provide an anti-human TSLP receptor antibody that specifically binds to human TSLP receptor and inhibits an action of human TSLP through human TSLP receptor.[Means for Solution] An anti-human TSLP receptor antibody had been studied by the present inventors, and an anti-human TSLP receptor antibody comprising a heavy chain variable region consisting of the amino acid sequence of amino acid numbers 1 to 118 of SEQ ID NO: 1 and a light chain variable region consisting of the amino acid sequence of amino acid numbers 1 to 108 of SEQ ID NO: 3 was provided. It was revealed that the anti-human TSLP receptor antibody inhibits expression of TARC mRNA induced by TSLP and production of MDC proteins, and suppressed an allergic reaction in a monkey Ascaris antigen sensitization model, and then the present invention was completed.
公开/授权文献
- US09328171B2 Anti-human TSLP receptor antibody 公开/授权日:2016-05-03
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