Embodiments of the present invention disclose an interference suppression method and a related device and system. The method includes: sending, on a specified time-frequency resource, a first reference signal or a first reference signal group to an interfered-with end; receiving interfering source information sent by the interfered-with end, where the interfering source information includes an interference identifier used for indicating whether a potential interfering source causes interference to the interfered-with end; and if the interference identifier in the interfering source information indicates that the potential interfering source sending the reference signal on the specified time-frequency resource causes interference to the interfered-with end, determining that the potential interfering source is an interfering source, otherwise, determining that the potential interfering source is a non-interfering source. According to the present invention, mutual interference between uplink and downlink signals of terminals located in a same cell or different cells can be suppressed.