Invention Application
US20160016860A1 METHODS FOR PHOSPHINE OXIDE REDUCTION IN CATALYTIC WITTIG REACTIONS
审中-公开
催化WITTIG反应中磷氧化物还原的方法
- Patent Title: METHODS FOR PHOSPHINE OXIDE REDUCTION IN CATALYTIC WITTIG REACTIONS
- Patent Title (中): 催化WITTIG反应中磷氧化物还原的方法
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Application No.: US14775931Application Date: 2014-03-14
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Publication No.: US20160016860A1Publication Date: 2016-01-21
- Inventor: Christopher O'BRIEN
- Applicant: DUBLIN CITY UNIVERSITY
- International Application: PCT/EP2014/055217 WO 20140314
- Main IPC: C07B37/04
- IPC: C07B37/04 ; C07F9/6568
Abstract:
A method for increasing the rate of phosphine oxide reduction, preferably during a Wittig reaction comprising use of an acid additive is provided. A room temperature catalytic Wittig reaction (CWR) the rate of reduction of the phosphine oxide is increased due to the addition of the acid additive is described. Furthermore, the extension of the CWR to semi-stabilized and non-stabilized ylides has been accomplished by utilization of a masked base and/or ylide-tuning.
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