发明申请
US20160009716A1 2 - (AZAINDOL-2-YL) BENZ IMIDAZOLES AS PAD4 INHIBITORS
有权
2 - (AZAINDOL-2-YL)BENZ IMIDAZOLES作为PAD4抑制剂
- 专利标题: 2 - (AZAINDOL-2-YL) BENZ IMIDAZOLES AS PAD4 INHIBITORS
- 专利标题(中): 2 - (AZAINDOL-2-YL)BENZ IMIDAZOLES作为PAD4抑制剂
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申请号: US14816246申请日: 2015-08-03
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公开(公告)号: US20160009716A1公开(公告)日: 2016-01-14
- 发明人: Stephen John Atkinson , Michael David Barker , Matthew Campbell , Hawa Diallo , Clement Douault , Neil Stuart Garton , John Liddle , Robert John Sheppard , Ann Louise Walker , Christopher Wellaway , David Matthew Wilson
- 申请人: GLAXO GROUP LIMITED
- 主分类号: C07D471/04
- IPC分类号: C07D471/04
摘要:
Compounds of formula (I) wherein; R1 is hydrogen or C1-6alkyl; R2 is hydrogen, C1-6alkyl, perhalomethylC0-5alkyl-O—, or C1-6alkoxy; R3 is hydrogen, C1-6alkyl, or C1-6alkoxyC1-6alkyl; R4 is hydrogen, C1-6alkyl, perhalomethylC1-6alkyl; or unsubstituted C3-6cycloalkylC1-6alkyl; A is C—R5 or N; B is C—R6 or N; D is C—R7 or N; with the proviso that at least one of A, B, and D, is N; R5 is hydrogen or C1-6alkyl; R6 is hydrogen or C1-6alkyl; R7 is hydrogen, C1-6alkyl, C1-6alkoxy, or hydroxy; R8 is hydrogen or C1-6alkyl, with the proviso that one of R4 and R8 is hydrogen; R9 is hydrogen or hydroxy; Rio is hydrogen or C1-6alkyl; and salts thereof are PAD4 inhibitors and may be useful in the treatment of various disorders, for example rheumatoid arthritis, vasculitis, systemic lupus erythematosus, ulcerative colitis, cancer, cystic fibrosis, asthma, cutaneous lupus erythematosis, and psoriasis.
公开/授权文献
- US09518054B2 2-(azaindol-2-yl) benz imidazoles as PAD4 inhibitors 公开/授权日:2016-12-13
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