An example method includes: classifying lung function risk based on patient attributes and a clinical protocol; generating alarms and incentives for compliance with the clinical protocol based on patient attributes, clinical protocol, and patient lung function risk; determining an orientation and position of a clinical device based on tagged feature(s) of the clinical device compared to identified patient feature(s); monitoring patient interaction with the clinical device; identifying a deviation from the clinical protocol based on the monitored patient interaction, a patient biometric indicator, and a desired setpoint state in the protocol; when a deviation is identified, providing feedback proportional to the deviation, the feedback including an adjustment with respect to the clinical protocol and/or the clinical device; and triggering at least one alarm and/or incentive based on deviation and feedback, wherein the alarm/incentives differs based on whether and to what extent deviation is identified and feedback.