发明申请
- 专利标题： HBV TREATMENT
- 专利标题（中）： 乙肝治疗
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申请号： US14731824申请日： 2015-06-05
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公开(公告)号： US20150344885A1公开(公告)日： 2015-12-03
- 发明人: Michael Wayne Graham , Peter French , York YuanYuan Zhu , YiXiang Lu , TieJun Li , YunCheng Sun , XiaoJun Tang , Li Shan
- 申请人： BENITEC BIOPHARMA LIMITED
- 优先权： CN201010521948.3 20101028; CN201010521962.3 20101028; CN201010521972.7 20101028; CN201010521975.0 20101028; CN201010521990.5 20101028; CN201010522003.3 20101028; CN201010522005.2 20101028
- 主分类号： C12N15/113
- IPC分类号： C12N15/113
摘要：
RNA interference (RNAi) agents and the use of the RNAi agents for treating hepatitis B infection in individuals, as well as pharmaceutical compositions containing the RNAi agents are provided. The RNAi agents, or constructs for expressing them are utilized to inhibit expression of at least one Hepatitis B virus (HBV) gene, wherein each agent comprises an effector sequence complementary to or substantially complementary to a predicted sequence transcribed from a target region. In some embodiments of the present invention, the agents have more than one effector sequence; wherein the multiple effectors may target the same region of an HBV gene, different (possibly overlapping) regions of the same gene and/or different HBV genes.
公开/授权文献
- US09410154B2 HBV treatment 公开/授权日：2016-08-09
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