发明申请
US20150314017A1 DISULFUR BRIDGE LINKERS FOR CONJUGATION OF A CELL-BINDING MOLECULE
审中-公开
用于结合细胞结合分子的分离桥连接器
- 专利标题： DISULFUR BRIDGE LINKERS FOR CONJUGATION OF A CELL-BINDING MOLECULE
- 专利标题（中）： 用于结合细胞结合分子的分离桥连接器
-
申请号： US14799712申请日： 2015-07-15
-
公开(公告)号： US20150314017A1公开(公告)日： 2015-11-05
- 发明人: Robert Yongxin Zhao
- 申请人： Dr. Robert Yongxin Zhao , SUZHOU M-CONJ BIOTECH CO., LTD
- 申请人地址： CN Suzhou City US MA Lexington
- 专利权人： SUZHOU M-CONJ BIOTECH CO., LTD,Dr. Robert Yongxin Zhao
- 当前专利权人： SUZHOU M-CONJ BIOTECH CO., LTD,Dr. Robert Yongxin Zhao
- 当前专利权人地址： CN Suzhou City US MA Lexington
- 主分类号： A61K47/48
- IPC分类号： A61K47/48 ; C07C243/28 ; C07D207/452 ; C07D403/14 ; C07C311/55 ; C07D213/71 ; C07K5/065 ; A61K45/06 ; C07C275/50
摘要：
The present invention relates to novel disulfur bridge linkers containing hydrazine used for the specific conjugation of compounds/cytotoxic agents to a cell-binding molecule, through bridge linking a pair of thiols on the cell-binding molecule. The invention also relates to methods of making such linkers, and of using such linkers in making homogeneous conjugates, as well as of application of the conjugates in treatment of cancers, infections and autoimmune disorders.
公开/授权文献
信息查询
