发明申请
US20150274662A1 4-CARBOXAMIDO-ISOINDOLINONE DERIVATIVES AS SELECTIVE PARP-1 INHIBITORS
审中-公开
作为选择性PARP-1抑制剂的4-CARBOXAMIDO-ISOINDOLINONE衍生物
- 专利标题： 4-CARBOXAMIDO-ISOINDOLINONE DERIVATIVES AS SELECTIVE PARP-1 INHIBITORS
- 专利标题（中）： 作为选择性PARP-1抑制剂的4-CARBOXAMIDO-ISOINDOLINONE衍生物
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申请号： US14438410申请日： 2013-10-23
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公开(公告)号： US20150274662A1公开(公告)日： 2015-10-01
- 发明人: Gianluca Mariano Enrico Papeo , Mikhail Yurievitch Krasavin , Paolo Orsini , Alessandra Scolaro
- 申请人： NERVIANO MEDICAL SCIENCES S.R.L.
- 申请人地址： IT Nerviano (MI)
- 专利权人： NERVIANO MEDICAL SCIENCES S.r.L.
- 当前专利权人： NERVIANO MEDICAL SCIENCES S.r.L.
- 当前专利权人地址： IT Nerviano (MI)
- 优先权： EP12190130.0 20121026
- 国际申请： PCT/EP2013/072165 WO 20131023
- 主分类号： C07D209/44
- IPC分类号： C07D209/44 ; C07D401/06 ; A61K31/4725 ; A61K31/4188 ; A61K31/5377 ; A61K31/4439 ; A61K31/496 ; A61K31/4035 ; A61K31/454
摘要：
There are provided substituted 4-carboxamido-isoindolinone derivatives which selectively inhibit the activity of poly (ADP-ribose) polymerase PARP-1 with respect to poly (ADP-ribose) polymerase PARP-2. The compounds of this invention are therefore useful in treating diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of inflammation. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing pharmaceutical compositions comprising these compounds.
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