发明申请
- 专利标题： BIODEGRADABLE HYDROGEL FOR POLYNUCLEOTIDE DELIVERY
- 专利标题（中）： 用于多核苷酸交付的生物可降解水凝胶
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申请号： US14435378申请日： 2013-10-15
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公开(公告)号： US20150267196A1公开(公告)日： 2015-09-24
- 发明人: Eben Alsberg , Minh Khanh Nguyen , Cong Huynh , Alex Gilewski , Matt Levy , Vincent Rotello , Gulen Yesilbag , Oju Jeon
- 申请人： CASE WESTERN RESERVE UNIVERSITY
- 国际申请： PCT/US2013/065145 WO 20131015
- 主分类号： C12N15/113
- IPC分类号： C12N15/113
摘要：
A composition includes a biodegradable hydrogel that includes a hydrogel forming base polymer and a plurality of physiologically degradable ester linkages, amide linkages, azide-alkyne cycloaddition linkages, acrylate-thiol linkages, urethane linkages, and/or methacrylate-thiol linkages, a polynucleotide coupling polymeric molecule; and a polynucleotide. The polynucleotide is released under physiological conditions in a spatial and/or temporally controlled or predetermined manner from the composition.
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