发明申请
US20150265575A1 PHARMACEUTICAL COMPOSITION ON THE BASIS OF PHYTO-NUTRIENTS WITH INCREASED BIOAVAILABILITY, HAVING ANTI-TUMOR ACTIVITY, AND METHOD FOR PRODUCING SAID COMPOSITION (ALTERNATIVES)
有权
具有增加的生物可利用性,具有抗肿瘤活性的生物营养物质的基础上的药物组合物和用于生产合成组合物的方法(替代物)
- 专利标题: PHARMACEUTICAL COMPOSITION ON THE BASIS OF PHYTO-NUTRIENTS WITH INCREASED BIOAVAILABILITY, HAVING ANTI-TUMOR ACTIVITY, AND METHOD FOR PRODUCING SAID COMPOSITION (ALTERNATIVES)
- 专利标题(中): 具有增加的生物可利用性,具有抗肿瘤活性的生物营养物质的基础上的药物组合物和用于生产合成组合物的方法(替代物)
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申请号: US14435846申请日: 2013-07-19
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公开(公告)号: US20150265575A1公开(公告)日: 2015-09-24
- 发明人: Vsevolod Ivanovich Kiselev
- 申请人: NORDIC LABS LIMITED
- 申请人地址: GB Newhouse, Lanarkshire
- 专利权人: NORDIC LABS LIMITED
- 当前专利权人: NORDIC LABS LIMITED
- 当前专利权人地址: GB Newhouse, Lanarkshire
- 优先权: RU2012144002 20121016
- 国际申请: PCT/RU2013/000568 WO 20130719
- 主分类号: A61K31/404
- IPC分类号: A61K31/404 ; A61K9/00 ; A61K31/121 ; A61K31/353 ; A61K31/05
摘要:
A pharmaceutical composition for peroral delivery of phyto-nutrients includes at least one phyto-nutrient from the following series: epigallocatechin-3-gallate, diindolylmethane, genestein, resveratrol, curcumine, and a solubilizer—a polyvinylcaprolactam/polyvinylacetate/polyethyleneglycol graft copolymer with an average molecular mass of 90000-140000 g/mol at a mass ratio of at least one phyto-nutrient and solubilizer of 1/5 to 1/1. The composition can additionally include a pharmaceutically acceptable carrier. The composition may be produced by dissolving the solubilizer in an organic solvent, dissolving at least one phyto-nutrient in the same organic solvent, mixing the resulting solutions, and distilling off the solvent in vacuo. The resulting mixture is heated to 45-50° C. with constant stirring and, after distillation, the product is dried in vacuo. Ethanol, acetone, or isopropanol can be used as the organic solvent. Alternatively, the composition may be produced by dry mixing the powders of the solubilizer and of at least one phyto-nutrient.
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