发明申请
- 专利标题： Method for In-Vitro Preparation of Double-Layered Virus-Like Particles of Rotavirus
- 专利标题（中）： 轮状病毒双层病毒样颗粒体外制备方法
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申请号： US14429586申请日： 2013-06-24
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公开(公告)号： US20150252334A1公开(公告)日： 2015-09-10
- 发明人: Shengxiang Ge , Tingdong Li , Qingshun Guo , Feihai Xu , Jun Zhang , Ningshao Xia
- 申请人： XIAMEN UNIVERSITY , XIAMEN INNOVAX BIOTECH CO., LTD.
- 优先权： CN201210350365.8 20120920
- 国际申请： PCT/CN2013/077736 WO 20130624
- 主分类号： C12N7/00
- IPC分类号： C12N7/00
摘要：
The invention relates to a method for preparing double-layered virus-like particles of rotavirus in vitro. The method comprises the following steps: purifying rotavirus VP6 proteins from a lysis supernatant, and in vitro assembling double-layered virus-like particles consisting of VP2 proteins and VP6 proteins, wherein the proteins and the virus-like particles can be used for preventing or reducing the clinical symptoms caused by rotavirus infection.
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