发明申请
US20150224141A1 METHODS OF USING SMALL COMPOUNDS TO ENHANCE MYELOID DERIVED SUPPRESSOR CELL FUNCTION FOR TREATING AUTOIMMUNE DISEASES
审中-公开
使用小化合物增强麻醉剂衍生抑制因子细胞功能治疗自身免疫性疾病的方法
- 专利标题： METHODS OF USING SMALL COMPOUNDS TO ENHANCE MYELOID DERIVED SUPPRESSOR CELL FUNCTION FOR TREATING AUTOIMMUNE DISEASES
- 专利标题（中）： 使用小化合物增强麻醉剂衍生抑制因子细胞功能治疗自身免疫性疾病的方法
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申请号： US14591185申请日： 2015-01-07
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公开(公告)号： US20150224141A1公开(公告)日： 2015-08-13
- 发明人: Shu-Hsia Chen
- 申请人： Icahn School of Medicine at Mount Sinai
- 主分类号： A61K35/15
- IPC分类号： A61K35/15 ; A61K31/416 ; A61K31/785
摘要：
Methods for enhancing the suppressive function of myeloid derived suppressor cells (MDSCs) for the treatment of autoimmune diseases using small compounds are disclosed. In certain aspects, the small compounds are glatiramer acetate and mitogen activated protein (MAP) kinase inhibitors. In other aspects, these methods include the administration of exogenous MDSCs or the use of endogenous MDSCs mobilized using stem cell mobilizers. In yet other aspects, compositions containing MDSCs and small compounds of the invention are provided.
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