The present invention relates to a plate-type heat exchange reactor and a method of manufacturing thereof, and there is provided a method of manufacturing a plate-type heat exchange reactor and a plate-type heat exchange reactor manufactured in the manufacturing method, the method including the steps of preparing side surface plates respectively provided with a plurality of slits formed in parallel along a longitudinal direction; arranging two side surface plates in a vertical direction to face each other with a space therebetween; forming a plurality of fluid passage channels by inserting a plurality of fluid passage partition walls into the slits provided on the two side surface plates in parallel in a horizontal direction; and bonding the side surface plates and the fluid passage partition walls.