A system and method for mapping an address space to a non-power-of-two number of memory channels. Addresses are translated and interleaved to the memory channels such that each memory channel has an equal amount of mapped address space. The address space is partitioned into two regions, and a first translation function is used for memory requests targeting the first region and a second translation function is used for memory requests targeting the second region. The first translation function is based on a first set of address bits and the second translation function is based on a second set of address bits.