发明申请
US20140371203A1 Thieno- and furo - pyrimidines and pyridines, useful as potassium channel inhibitors
有权
噻吩并呋喃并嘧啶和吡啶，可用作钾通道抑制剂
- 专利标题： Thieno- and furo - pyrimidines and pyridines, useful as potassium channel inhibitors
- 专利标题（中）： 噻吩并呋喃并嘧啶和吡啶，可用作钾通道抑制剂
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申请号： US14358722申请日： 2012-11-15
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公开(公告)号： US20140371203A1公开(公告)日： 2014-12-18
- 发明人: David Madge , Fiona Chan , Derek Edward John , Simon D. Edwards , Richard Blunt , Basil Hartzoulakis , Lindsay Brown
- 申请人： XENTION LIMITED
- 优先权： GB1119703.5 20111115; GB1214250.1 20120809
- 国际申请： PCT/GB2012/052842 WO 20121115
- 主分类号： C07D495/04
- IPC分类号： C07D495/04
摘要：
The present invention provides compounds of formula (I): (Formula (I); wherein A, R1, R2, R3I, V, X, and Z are defined herein, which are potassium channel inhibitors. The invention further provides pharmaceutical compositions comprising the compounds of formula (I) and their use in therapy, in particular in treatment of diseases or conditions that are mediated by Kir3.1 and/or Kir3.4 or any heteromultimers thereof, or that require inhibition of Kir3.1 and/or Kir3.4 or any heteromultimers thereof.
公开/授权文献
- US09290511B2 Thieno-pyrimidines, useful as potassium channel inhibitors 公开/授权日：2016-03-22
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