发明申请
US20140348777A1 Polysorbitol-Based Osmotically Active Transporter and Gene Therapy Using Same
有权
基于聚山梨糖醇的渗透活性转运体和使用相同的基因治疗
- 专利标题： Polysorbitol-Based Osmotically Active Transporter and Gene Therapy Using Same
- 专利标题（中）： 基于聚山梨糖醇的渗透活性转运体和使用相同的基因治疗
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申请号： US14007064申请日： 2011-08-12
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公开(公告)号： US20140348777A1公开(公告)日： 2014-11-27
- 发明人: Myung Haing Cho , Chong Su Cho
- 申请人： Myung Haing Cho , Chong Su Cho
- 申请人地址： KR Seoul
- 专利权人： SNU R&DB FOUNDATION
- 当前专利权人： SNU R&DB FOUNDATION
- 当前专利权人地址： KR Seoul
- 优先权： KR10-2011-0027201 20110325
- 国际申请： PCT/KR11/05955 WO 20110812
- 主分类号： A61K48/00
- IPC分类号： A61K48/00 ; C08G63/91 ; C08G63/685
摘要：
The present invention relates to a biodegradable polysorbitol-based osmotically active transporter (PSOAT) and gene therapy using the same as a gene carrier. The biodegradable polysorbitol-based osmotically active transporter (PSOAT) of the present invention includes a sorbitol skeleton, which imparts an osmotic pressure to the cell membrane to improve membrane permeability, thereby exhibiting remarkably improved transfection efficiency. Further, the polysorbitol-based osmotically active transporter of the present invention exhibits high DNA binding ability, effectively protects DNA from nuclease, exhibits physicochemical properties suitable for use as a gene carrier, and has very low cytotoxicity in vitro and in vivo, thereby capable of being used as a gene carrier for gene therapy.
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