发明申请
- 专利标题： NO- AND H2S- RELEASING COMPOUNDS
- 专利标题（中）： NO-和H2S-释放化合物
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申请号： US13981378申请日： 2012-08-15
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公开(公告)号： US20140221316A1公开(公告)日： 2014-08-07
- 发明人: Khosrow Kashfi , Ravinder Kodela
- 申请人： Khosrow Kashfi , Ravinder Kodela
- 申请人地址： US NY New York
- 专利权人： RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK
- 当前专利权人： RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK
- 当前专利权人地址： US NY New York
- 国际申请： PCT/US12/50922 WO 20120815
- 主分类号： C07C203/04
- IPC分类号： C07C203/04 ; C07D413/12 ; C07F9/6578 ; C07C327/48 ; C07C331/28 ; C07F9/6558 ; C07D339/04 ; C07D271/08
摘要：
This disclosure relates to novel compounds containing an H2S releasing moiety and a nitric oxide (NO) releasing moiety covalently linked with a core (e.g., a salicylic acid moiety) and the use of such compounds in treating inflammatory diseases, including cancers. Therapeutic potency of these compounds is significantly higher than NSAIDs containing a H2S-releasing moiety alone (HS-NSAIDs) and NSAID containing a NO-releasing moiety alone (NO-NSAIDs). The compounds, in addition, exhibit reduced side effect, e.g., reduced stomach ulcers, upon administration.
公开/授权文献
- US09688607B2 No- and H2S-releasing compounds 公开/授权日：2017-06-27
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