There is provided a cartridge for a medication dispensing apparatus having a roll-rotating drum, the cartridge including a cartridge case having an open outlet formed on a bottom thereof so as to dispense medication; a drum installed inside of the cartridge case so as to selectively open and/or close the outlet; and a cartridge base having the cartridge case installed thereto, wherein projections projected downward and grooves recessed upward are formed on a bottom of the drum, alternatively, and a concave-convex part having protruding portion protruding upward are formed on a bottom surface of the cartridge case at intervals.