- 专利标题： REIC-EXPRESSING ADENOVIRUS VECTOR
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申请号： US14119772申请日： 2012-05-25
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公开(公告)号： US20140147917A1公开(公告)日： 2014-05-29
- 发明人: Hiromi Kumon , Namho Huh , Masakiyo Sakaguchi , Masami Watanabe
- 申请人： Hiromi Kumon , Namho Huh , Masakiyo Sakaguchi , Masami Watanabe
- 专利权人： Momotaro-Gene Inc.,National University Corporation Okayama University
- 当前专利权人： Momotaro-Gene Inc.,National University Corporation Okayama University
- 优先权： JP20111-117321 20110525
- 国际申请： PCT/JP2012/064250 WO 20120525
- 主分类号： C12N15/86
- IPC分类号： C12N15/86
摘要：
An objective of the present invention is to provide an adenovirus vector expressing a REIC/Dkk-3 protein at a high level and containing a DNA construct for expression of REIC/Dkk-3 DNA, wherein the DNA construct is prepared by ligating, from the 5′ terminal side, (i) a CMV promoter, (ii) REIC/Dkk-3 DNA, (iii) a polyA addition sequence, and (iv) enhancers prepared by linking an hTERT (Telomerase Reverse Transcriptase) enhancer, an SV40 enhancer, and a CMV enhancer in this order.
公开/授权文献
- US09222107B2 REIC-expressing adenovirus vector 公开/授权日：2015-12-29
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