Invention Application
US20130287700A1 COMPOUNDS FOR THE DIAGNOSIS OF NEURODEGENERATIVE DISORDERS ON THE OLFACTORY EPITHELIUM
审中-公开
用于诊断上消化道上皮神经损伤的疾病的化合物
- Patent Title: COMPOUNDS FOR THE DIAGNOSIS OF NEURODEGENERATIVE DISORDERS ON THE OLFACTORY EPITHELIUM
- Patent Title (中): 用于诊断上消化道上皮神经损伤的疾病的化合物
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Application No.: US13825186Application Date: 2011-09-20
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Publication No.: US20130287700A1Publication Date: 2013-10-31
- Inventor: Boris Schmidt , Daniel Kieser , Alexander Boländer , Jochen Herms , Roland Heyny-Von Haussen , Jiamin Gu
- Applicant: Boris Schmidt , Daniel Kieser , Alexander Boländer , Jochen Herms , Roland Heyny-Von Haussen , Jiamin Gu
- Applicant Address: DE Darmstadt DE Darmstadt DE Munchen
- Assignee: KLINIKUM DARMSTADT GMBH,TECHNISCHE UNIVERSITAT DARMSTADT,LUDWIG-MAXIMILIANS-UNIVERSITAT MUNCHEN
- Current Assignee: KLINIKUM DARMSTADT GMBH,TECHNISCHE UNIVERSITAT DARMSTADT,LUDWIG-MAXIMILIANS-UNIVERSITAT MUNCHEN
- Current Assignee Address: DE Darmstadt DE Darmstadt DE Munchen
- Priority: DE102010045797.3 20100920
- International Application: PCT/DE2011/001780 WO 20110920
- Main IPC: A61K49/00
- IPC: A61K49/00 ; G01N21/64
Abstract:
Subject of the present invention are compounds with high affinity for the Aβ protein, α-synuclein or for Tau-PHF aggregates, which are suitable as preferably fluorescent probes for the in vivo diagnosis of neurodegenerative disorders like e.g. Alzheimer's disease and Parkinson's disease. The compounds are characterized by suitable physicochemical properties (excitation wavelength, emission wavelength, Stokes shift, extinction) as well as a high affinity and selectivity for the target proteins.
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