A method includes creating a plurality of data fragments from a single data unit. The method also includes transmitting the plurality of data fragments to a receiver and receiving an acknowledgement from the receiver after transmitting a last data fragment of the plurality of data fragments. The method further includes selectively interpreting the acknowledgement as a multi-fragment acknowledgement (MFA) in response to a value of a fragment sequence number (FGSN) of the last data fragment. The MFA indicates receipt or non-receipt by the receiver of each of the plurality of data fragments of the single data unit.