A communication system and method are disclosed. The system includes a receiver to receive and process a transmission signal provided from a transmitter based on a digital input signal, and to generate a receiver signal that indicates eye characteristics associated with transmission characteristics of the processed transmission signal. The transmission characteristics can be set by a digital filter associated with the transmitter based on filter parameters. The system further includes a transmitter training system to implement a plurality of experiments based on implementing Design of Experiments (DOE) to provide the filter parameters to the transmitter and to evaluate the corresponding eye characteristics to determine an output set of filter parameters.