Device, system, and method of multi-user multi-input-multi-output (MIMO) wireless communication. In some embodiments, a wireless communication device (102) may be capable of receiving a plurality of channel feedback transmissions from a plurality of user devices (104, 106, 108) respectively, wherein a channel feedback transmission from a user device of the user devices includes partial information relating to a MIMO channel matrix between the wireless communication unit and the user device; and transmitting a multi -user MIMO transmission to the plurality of user devices according to a MIMO beamforming scheme, wherein the MIMO beamforming scheme is based on the plurality of channel feedback transmissions.