A nuclear reactor can include a pressure vessel for containing a pressurized moderator at a first pressure. The nuclear reactor can also include a plurality of fuel channels for a coolant fluid at a second pressure. The plurality of fuel channels are fluidly connected at inlet ends thereof to a coolant supply conduit and are adapted to receive nuclear fuel bundles and to be mounted within the pressure vessel and surrounded by the moderator. The outlet ends of the fuel channels are fluidly connected to a coolant outlet conduit to enable the coolant fluid to circulate from the coolant supply conduit through the fuel channels to the coolant outlet conduit. The plurality of fuel channels maintain separation between the coolant fluid circulating within the fuel channels and the moderator.