发明申请
- 专利标题： METHOD FOR ENANTIOSELECTIVE HYDROGENATION OF CHROMENES
- 专利标题（中）： 氯仿的选择性加氢方法
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申请号： US13608330申请日： 2012-09-10
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公开(公告)号： US20130116450A1公开(公告)日： 2013-05-09
- 发明人: Kenneth David Reginald SETCHELL , Victor Dmitrievich Sorokin
- 申请人： Kenneth David Reginald SETCHELL , Victor Dmitrievich Sorokin
- 申请人地址： US OH Cincinnati US OH Cincinnati
- 专利权人： GIRINDUS AMERICA, INC.,CHILDREN'S HOSPITAL MEDICAL CENTER
- 当前专利权人： GIRINDUS AMERICA, INC.,CHILDREN'S HOSPITAL MEDICAL CENTER
- 当前专利权人地址： US OH Cincinnati US OH Cincinnati
- 主分类号： C07D311/58
- IPC分类号： C07D311/58 ; C07D311/38
摘要：
A method for preparing an enantiomeric chromane, by asymmetrically hydrogenating a chromene compound in the presence of an Ir catalyst having a chiral ligand. The method includes the enantioselective preparation of enantiomeric equol. A preferred Ir catalyst has a chiral phosphineoxazoline ligand. Enantiomeric chromanes of high stereoselective purity can be obtained.
公开/授权文献
- US08716497B2 Method for enantioselective hydrogenation of chromenes 公开/授权日：2014-05-06
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