发明申请
US20130071475A1 Method For Producing An Oral Pharmaceutical Form With Immediate Disintegration And Active Ingredient Release
审中-公开
生产具有立即崩解和活性成分释放的口服药物形式的方法
- 专利标题: Method For Producing An Oral Pharmaceutical Form With Immediate Disintegration And Active Ingredient Release
- 专利标题(中): 生产具有立即崩解和活性成分释放的口服药物形式的方法
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申请号: US13677740申请日: 2012-11-15
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公开(公告)号: US20130071475A1公开(公告)日: 2013-03-21
- 发明人: Hans-Ulrich PETEREIT , Christian MEIER , Andreas GRYCZKE
- 申请人: Hans-Ulrich PETEREIT , Christian MEIER , Andreas GRYCZKE
- 优先权: DE10304403.5 20030128
- 主分类号: A61J3/10
- IPC分类号: A61J3/10 ; A61K31/192 ; A61K9/14
摘要:
The invention relates to a method for producing an oral form of administration which decomposes immediately and releases active ingredients in the mouth. According to said method, (a) an anionic pharmaceutical active ingredient is intensively mixed with (b) a copolymer consisting of radically polymerized C1-C4 esters of the acrylic acid or methacrylic acid and other (meth)acrylate monomers containing functional tertiary amino groups, and (c) between 5 and 50 wt. %, in relation to (b), of a C12-C22 carboxylic acid in the melted mass; the mixture is solidified and ground to form a powder containing active ingredients having an average particle size of 200 μm or less; and the powder is encapsulated in a water-soluble matrix consisting of pharmaceutically standard adjuvants, on the condition that no more than 3 wt. %, in relation to the copolymer, of emulsifiers with an HLB value of at least 14 must be contained therein. The invention also relates to the powder containing active ingredients and the uses of the same.
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